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   樊代明
  男,中国工程院院士,肿瘤生物学国家重点实验室主任、中华消化学会主任委员、中国抗癌协会副理事长、由104个成员国参加的世界胃肠病大会主席、国家教育部长江学者奖励计划特聘教授,是首批国家优秀中青年人才专项基金及国家杰出青年基金的获得者。曾先后在日本东京国立癌症中心和比利时鲁汶大学作访问学者。
   现担任BMC Cancer、J Dig Dis等4种杂志主编或副主编,以及Gut and Liver、J Clin Gastroenterology、Aliment Pharmacol Ther、J Gastroenterol Hepatol等5种国际杂志的编委。长期从事消化系疾病的基础及临床研究工作,特别是在胃癌发生、发展的分子机制及防治研究中做出了突出贡献:① 首次提出了胃癌“三级四步”序贯预防策略的新思想,指导了胃癌预防工作的开展;② 研制出胃癌早癌分子预警的新方法,提升了

我国胃癌早期诊断的水平;③ 发现一批与胃癌恶性生物学行为相关的分子群并研究了其调控机制,为胃癌诊治新靶点的发现奠定了基础。 先后承担国家“863”、“973”、国家攻关、国家重大支撑、国家自然科学基金重点项目等课题。获得2010年”973”国家重大计划项目首席科学家资助。开发了具有我国自主知识产权的国家I类诊断试剂——“胃癌免疫PCR血清诊断试剂盒”。2008年以第一完成人获得了迄今为止我国胃癌研究领域唯一的国家科技进步一等奖,以第一完成人获国家发明三等奖1项,还获国家科技进步二、三等奖各1项及省部级一等奖4项。主编专著9本。以第一作者或通讯作者在国际杂志发表论文277篇,包括Nat Clin Pract Oncol、Lancet、JAMA、Ann Intern Med、Hepatology、Gut、Plos Genet、Ann Surg、J Hepatol、Faseb J、Clin Cancer Res、J Biol Chem等高水平杂志,总影响因子926.39分,最高影响因子达28.6分,10篇主要论文他引785次。应邀在J Gastroen Hepatol等10种国际专业杂志作特邀综述12篇。主编《内科学》、《肿瘤研究前沿》、《抗性与变异》等专著11部。

38篇代表论文:
1 Liu J, Fan D. Hepatitis B in China. Lancet. 369(9573):1582-3. 2007 (IF 28.638)
2 Liu J, Han S, Ding J, Wu K, Miao J, Fan D. COX2-related multicentric mixed-type Castleman’s disease in a young man. Nature Clin Pract Oncol. 2(7):370-375. 2005 (IF 8.075)
3 Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S, Guo X, Wang B, Gang Y, Zhang Y, Li Q, Qiao T, Zhao Q, Nie Y, Fan D. MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor. PLoS Genet. 6(3):e1000879. 2010 (IF 9.532)
4 Li X, Zhang Y, Zhang Y, Ding J, Wu K, Fan D. Survival prediction of gastric cancer by a seven-microRNA signature. Gut. 59(5):579-85. 2010 (IF 9.357)
5 Zhang DX, Zhao PT, Xia L, Zhai HH, Zhang HB, Guo XG, Wu KC, Xu YM, Jia LT, Yang AG, Chen SY, Fan DM. Potent Inhibition of Human Gastric Cancer by HER2-directed Induction of Apoptosis with Anti-HER2 Antibody and Caspase-3 Fusion Protein. Gut. 59(3):292-9. 2010 (IF 9.357)
6 Hong L, Han Y, Zhang H, Li M, Gong T, Sun L, Wu K, Zhao Q, Fan D. The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma. Ann Surg. 251(6):1056-63. 2010 (IF 7.9)
7 Han G, Qi X, He C, Yin Z, Wang J, Xia J, Yang Z, Bai M, Meng X, Niu J, Wu K, Fan D. Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis. J Hepatol. in press 2010 [PMID: 20932597] (IF 7.818)
8 Liang J, Pan Y, Zhang D, Guo C, Shi Y, Wang J, Chen Y, Wang X, Liu J, Guo X, Chen Z, Qiao T, Fan D. Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS. FASEB J. 21(9):2247-2256. 2007 (IF 6.791)
9 Pan Y, Zhao L, Liang J, Liu J, Shi Y, Liu N, Zhang G, Jin H, Gao J, Xie H, Wang J, Liu Z, Fan D. Cellular prion protein promotes invasion and metastasis of gastric cancer. FASEB J. 20(11):1886-1888. 2006 (IF 6.721)
10 Liu J, Lian Z, Han S, Waye MM, Wang H, Wu MC, Wu K, Ding J, Arbuthnot P, Kew M, Fan D, Feitelson MA.  Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene. 25(7):1008-1017. 2006 (IF 6.582)
11 Sun S, Ning X, Zhang Y, Lu Y, Nie Y, Han S, Liu L, Du R, Xia L, He L, Fan D. Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition. Kidney Int. 75(12):1278-1287. 2009 (IF 6.193)
12 Hui X, Han Y, Liu Z, Liu J, Hong L, Zhao L, He L, Liang S, Cao S, Chen B, Yan K, Jin B, Chai N, Wang J, Wu K, Fan D. Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC. J Control Release. 131(2):86-93. 2008 (IF 5.69)
13 Jin H, Pan Y, Zhao L, Zhai H, Li X, Sun L, He L, Chen Y, Hong L, Du Y, Fan D. p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells. Neoplasia. 9(6):471-8. 2007 (IF 5.674)
14 Liu N, Bi F, Pan Y, Sun L, Xue Y, Shi Y, Yao X, Zheng Y, Fan D. Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 10(18): 6239-47. 2004 (IF 5.623)
15 Jin H, Wang Z, Liu L, Gao L, Sun L, Li X, Zhao H, Pan Y, Shi H, Liu N, Hong L, Liang J, Wu Q, Yang Z, Wu K, Fan D. R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. Mol Pharm. 7(1):156-68. 2010 (IF 5.408)
16 Hong L, Han Y, Han Y, Zhao Y, Zhang X, Qiao T, Chen Z, Fan D. Mechanisms of growth arrest by zinc ribbon domain-containing 1 (ZNRD1) in gastric cancer cells. Carcinogenesis. 28(8):1622-8. 2007 (IF 5.406)
17 Zhao L, Pan Y, Gang Y, Wang H, Jin H, Tie J, Xia L, Zhang Y, He L, Yao L, Qiao T, Li T, Liu Z, Fan D. Identification of GAS1 as an epirubicin resistance related gene in human gastric cancer cells with a partially randomized siRNA library. J Biol Chem. 284(39):26273-85. 2009 (IF 5.328)
18 Shi Y, Zhai H, Wang X, Wu H, Nie Y, Han Y, Zhang D, Xiao B, Wu K, Fan D. Multidrug-resistance-associated protein MGr1-Ag is identical to the human 37-kDa laminin receptor precursor. Cell Mol Life Sci. 59:1577-1583. 2002 (IF 5.259)
19 Du R, Xia L, Sun S, Lian Z, Zou X, Gao J, Xie H, Fan R, Song J, Li X, Liu J, Fan D. URG11 Promotes Gastric Cancer Growth and Invasion by Activation of beta-Catenin Signaling Pathway. J Cell Mol Med. 14(3):621-35. 2010 (IF 5.228)
20 Guo X, Shi Y, Gou Y, Li J, Han S, Zhang Y, Huo J, Ning X, Sun L, Chen Y, Sun S, Fan D. Human ribosomal protein S13 promotes gastric cancer growth through downregulating p27(Kip1). J Cell Mol Med. in press 2010 [PMID: 19912438] (IF 5.228)
21 Li X, Zhang Y, Shi Y, Dong G, Liang J, Han Y, Wang X, Zhao Q, Ding J, Wu K, Fan D. MicroRNA-107, an Oncogene MicroRNA that Regulates Tumor Invasion and Metastasis By Targeting DICER1 in Gastric Cancer: MiR-107 promotes gastric cancer invasion and metastasis. J Cell Mol Med. in press 2010 [PMID: 21029372] (IF 5.228)
22 Liang J, Wang J, Luo G, Pan Y, Han G, Wang X, Guo C, Zhang D, Yin F, Zhang X, Liu J, Wang J, Guo X, Wu K, Fan D. Function of PrP(C)(1-OPRD) in biological activities of gastric cancer cell lines. J Cell Mol Med. 13(11-12):4453-64. 2009 (IF 5.228)
23 Hong L, Piao Y, Han Y, Wang J, Zhang X, Du Y, Cao S, Qiao T , Chen Z, Fan D. Zinc ribbon domain-containing 1 (ZNRD1) mediates multidrug resistance of leukemia cells through regulation of P-glycoprotein and Bcl-2. Mol Cancer Ther. 4(12):1936-1942. 2005 (IF 5.171)
24 Liang S, Lin T, Ding J, Pan Y, Dang D, Guo C, Zhi M, Zhao P, Sun L, Hong L, Shi Y, Yao L, Liu J, Wu K, Fan D. Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer. J Mol Med. 84(9):764-773. 2006 (IF 5.157)
25 Hong L, Wu K, Fan D. Sildenafil as treatment for antidepressant-induced sexual dysfunction. JAMA. 300(20):2365. 2008 (IF 31.718)
26 Hong L, Wu K, Fan D. Drawing Conclusions about Short-Term Variability in Liver Function Test Results. Ann Intern Med. 149(2):144-145. 2008 (IF 17.457)
27 Hong L, Wu K, Fan D. Monitoring cholesterol levels: understanding variance and finding the most useful data. Ann Intern Med. 149(6):437. 2008 (IF 17.457)
28 Hong L, Wu K, Fan D. Effect of Testosterone Therapy versus Other Factors on the Self-reported Sexual Satisfaction of Premenopausal Women. Ann Intern Med. 149(5):361. 2008 (IF 17.457)
29 Yang Z, Wu Q, Fan D. Universal Insurance Coverage and Health Care Inequity. Ann Intern Med. 151(8):590-591. 2009 (IF 16.225)
30 Hong L, Wu K, Fan D. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation. 118(16):e668. 2008 (IF 14.595)
31 Liu N, Zhang H, Wu K, Fan D. What is the relationship between epidermal growth factor-like domain 7 and RhoC in metastasis of hepatocellular carcinoma? Hepatology. 51(6):2235-6. 2010 (IF 10.84)
32 Qi X, Han G, Fan D. The preferable treatment for cirrhotic portal vein thrombosis: Anticoagulation or transjugular intrahepatic portosystemic shunt? Hepatology. 51(2):713-714. 2010 (IF 10.84)
33 Li X, Wu K, Fan D. Insulin resistance and platelet count/spleen diameter ratio: Two simple, easy-to-get tests for predicting esophageal varices in cirrhosis. Hepatology. 49(4):1394. 2009 (IF 10.84)
34 Bai M, Han G, Qi X, Yin Z, Fan D. Two hypotheses for decreasing hepatic encephalopathy risk after transjugular intrahepatic portosystemic shunt. Hepatology. 51(6):2236-7. 2010 (IF 10.84)
35 Li X, Zhang Y, Wu K, Fan D. Serum cytokeratin-18 fragment level: A noninvasive biomarker for not only nonalcoholic steatohepatitis, but also alcoholic steatohepatitis. Hepatology. 51(5):1865-6. 2010 (IF 10.84)
36 Qi X, Han G, Wang J, Wu K, Fan D. Degree of portal vein thrombosis. Hepatology. 51(3):1089-1090. 2010 (IF 10.84)
37 Li X, Wu K, Fan D. Serum Golgi Phosphoprotein 2 level: A better marker than alpha-fetoprotein for diagnosing early hepatocellular carcinoma. Hepatology. 50(5):1682. 2009 (IF 10.84)
38 Qi X, Han G, Wu K, Fan D. A confusing relationship between child-turcotte-pugh class a and compensated cirrhosis. Am J Gastroenterol. 105(2):470-2. 2010 (IF 6.012)

12篇特邀综述:
1 Hong L, Han Y, Li S, Yang J, Zheng J, Zhang H, Zhao Q, Wu K, Fan D. The malignant phenotype-associated microRNA in gastroenteric, hepatobiliary and pancreatic carcinomas. Expert Opin Biol Ther. in press 2010 [PMID: 20977295]
2 Li X, Wu K, Fan D. CIAPIN1 as a therapeutic target in cancer. Expert Opin Ther Targets. 14(6):603-10. 2010
3 Zhang D, Fan D. New insights into the mechanisms of gastric cancer multidrug resistance and future perspectives. Future Oncol. 6(4):527-37. 2010
4 Wu K, Nie Y, Guo C, Chen Y, Ding J, Fan D. Molecular basis of therapeutic approaches to gastric cancer. J Gastroenterol Hepatol. 24(1):37-41. 2009
5 Zhao L, Liu Z, Fan D. Overview of mimotopes and related strategies in tumor vaccine development. Expert Rev Vaccines. 7(10):1547-1555. 2008
6 Hong L, Fan D. Cancer mucosa antigens: novel immunotherapeutic targets. Expert Opin Ther Targets. 12(6):749-56. 2008
7 Zhang D, Fan D. Multidrug resistance in gastric cancer: recent research advances and ongoing therapeutic challenges. Expert Rev Anticancer Ther. 7(10):1369-78. 2007
8 Hong L, Chen Z, Zhang X, Xia L, Han Z, Lu Y, Jin H, Song J, Qiao T, Fan D. Zinc ribbon domain containing 1 protein: modulator of multidrug resistance, tumorigenesis and cell cycle. Exp Oncol. 28(4):258-62. 2006
9 Zhang D, Chen Y, Fan D. MG7 mimotope-based DNA vaccination for gastric cancer. Expert Rev Vaccines. 5(2):223-31. 2006
10 Liang J, Ge F, Lu Y, Wang J, Zhai H, Yao L, Li J, Ji Q, Guo X, Liu Z, Fan D. Role of prpc related to apoptosis. EXCLI Journal. 5:11-24. 2006
11 Fan D, Zhang X, Chen X, Mou Z, Hu J, Zhou S, Ding J, Wu K. Bird’s-eye view on gastric cancer research of the past 25 years. J Gastroenterology Hepatology. 20(3):360-365. 2005
12 Bi F, Liu N, Fan D. Small interfering RNA: a new tool for gene therapy. Curr Gene Ther. 3(5):411-417. 2003

主编专著:
  1. 胡家露,樊代明主编. 内科学. 北京:高等教育出版社,2001
  2. 樊代明主编. 抗性与变异. 西安:第四军医大学出版社,2003
  3. 樊代明主编. 肿瘤研究前沿(第一卷). 西安:西安交通大学出版社,2001
  4. 樊代明主编. 肿瘤研究前沿(第二卷). 西安:西安交通大学出版社,2002
  5. 樊代明主编. 肿瘤研究前沿(第三卷). 西安:西安交通大学出版社,2003
  6. 樊代明主编. 肿瘤研究前沿(第四卷). 西安:西安交通大学出版社,2004
  7. 樊代明主编. 肿瘤研究前沿(第五卷). 西安:西安交通大学出版社,2005
  8. 樊代明主编. 肿瘤研究前沿(第六卷). 西安:第四军医大学出版社,2006
  9. 樊代明主编. 肿瘤研究前沿(第七卷). 西安:第四军医大学出版社,2007
  10. 樊代明主编. 肿瘤研究前沿(第八卷). 西安:第四军医大学出版社,2008
  11. 樊代明主编. 肿瘤研究前沿(第九卷). 西安:第四军医大学出版社,2009

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